Theme | Description |
Basics of SPECT and PET Imaging | - SPECT (Single Photon Emission Computed Tomography):
- Uses gamma-emitting radioisotopes (e.g., Technetium-99m).
- Detects blood flow, receptor activity, and metabolic function.
- Often used in brain, heart, and bone imaging.
- PET (Positron Emission Tomography):
- Uses positron-emitting tracers like FDG (fluorodeoxyglucose).
- FDG mimics glucose, highlighting areas of high glycolytic activity—often cancerous tissue.
- PET is a cornerstone in oncology for staging, monitoring, and recurrence detection.
Insight: These imaging tools reveal cancer’s metabolic fingerprint—its addiction to glucose and glutamine. |
| Standard of Care vs. Metabolic Targeting | - Standard of Care:
- Surgery, chemotherapy, radiation, and immunotherapy.
- Often toxic, with long-term side effects and limited efficacy in late-stage cancers.
- Metabolic Therapy (Seyfried’s Protocol):
- Eliminate glucose: via ketogenic diet and fasting.
- Block glutamine: using drugs like DON (6-diazo-5-oxo-L-norleucine), ivermectin, or fenbendazole.
- Goal:
- Starve cancer cells of their two essential fuels.
Cancer cells are metabolically inflexible. Normal cells adapt to ketones; cancer cells cannot. |
| Fermentation Energy Production: Seyfried’s Evidence | - Warburg Effect:
- Cancer cells favor glycolysis even in oxygen-rich environments.
- Seyfried’s Expansion:
- Shows that cancer cells also ferment glutamine—a second fuel source.
- Fermentation occurs inside and outside mitochondria, bypassing oxidative phosphorylation.
- This dual-fuel fermentation is necessary and sufficient for cancer survival.
Case studies and animal models show tumor regression when both glucose and glutamine are restricted. |
